Which road connected Chicago and Los Angeles?

Route 66, often referred to as the "Main Street of America," is the historic highway that famously connected Chicago to Los Angeles. Established in 1926, this highway became an iconic symbol of freedom and mobility in America, embodying the spirit of road travel and adventure during a time when automobiles became increasingly accessible. As it runs through various states, including Illinois, Missouri, Kansas, Oklahoma, Texas, New Mexico, Arizona, and California, Route 66 holds a significant place in American culture, representing a journey from the Midwest to the West Coast. It has been depicted in numerous songs, movies, and literature, contributing to its status as a cherished part of American history.

Other options represent different highways or routes; Interstate 10 runs from the West Coast to the East Coast but does not connect Chicago directly to Los Angeles. Highway 101 travels primarily along the coast of California and does not serve the direct route between these two cities. The Pacific Coast Highway is a scenic coastal route in California, again not linking Chicago to Los Angeles. Thus, Route 66 is recognized as the correct answer due to its historical significance and direct connection between these two major cities.